The Salem to Karumathampatti bus route covers approximately 141 kms and takes about 2 hrs 26 mins. A total of 20 direct buses operated by 7 bus operators run on this route. The first bus departs at 02:30, and the last bus leaves at 22:30.
Major boarding points in Salem include Attur, Avr Roundana, Ayodhiyapatinam, Kondalampatti, Mettupatti, Omalur, Salem New Bus Stand, Seelanaickenpatti, Valappadi, Vinayaka Mission University, while common drop locations in Karumathampatti are Karumathampatti.
RTC and private operators such as SNB Travels offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 599 - INR 1799.00 depending on the bus type and features.



