The Payyoli to Thiruvananthapuram bus route covers approximately 425 kms and takes about 9 hrs 48 mins. A total of 8 direct buses operated by 6 bus operators run on this route. The first bus departs at 20:40, and the last bus leaves at 23:15.
Major boarding points in Payyoli include Payyoli, while common drop locations in Thiruvananthapuram are Aristo Junction, Attingal, Chakka Pass, Infosys Campus, Kaniyapuram,, Kazhakootam, Kesavadasapuram, Pattam, Sreekaryam, Techno Park.
RTC and private operators such as EMERALD TRAVELS offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 899 - INR 1999.00 depending on the bus type and features.



