The Natham to Karaikudi bus route covers approximately 70 kms and takes about 1 hrs 48 mins. A total of 2 direct buses operated by 2 bus operators run on this route. The first bus departs at 02:30, and the last bus leaves at 03:10.
Major boarding points in Natham include Avr Roundana, while common drop locations in Karaikudi are New Bus Stand.
RTC and private operators such as offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 400 - INR 640.00 depending on the bus type and features.



